Cytoplasmic filaments and gap junctions in epithelial cells and myofibroblasts during wound healing

نویسندگان

  • G Gabbiani
  • C Chaponnier
  • I Hüttner
چکیده

During the healing of an experimental skin wound, epidermal cells and granulation tissue fibroblasts (myofibroblasts) develop an extensive cytoplasmic contactile apparatus. Concurrently, the proportion of epidermal cell surface occupied by gap junctions increases when compared to normal skin, and newly formed gap junctions appear between myofibroblasts; this suggests that epidermal cell migration and granulation tissue contraction are synchronized phenomena.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Myofibroblast communication is controlled by intercellular mechanical coupling.

Neoformation of intercellular adherens junctions accompanies the differentiation of fibroblasts into contractile myofibroblasts, a key event during development of fibrosis and in wound healing. We have previously shown that intercellular mechanical coupling of stress fibres via adherens junctions improves contraction of collagen gels by myofibroblasts. By assessing spontaneous intracellular Ca2...

متن کامل

Functional gap junctions in corneal fibroblasts and myofibroblasts.

PURPOSE Within the corneal stroma, keratocytes communicate through gap junctions. These plasma membrane channels, which connect the cytoplasm of adjacent cells, are composed of connexins. In a cell culture model, an investigation was conducted to determine whether connexin-based gap junction intercellular communication is present in fibroblasts and myofibroblasts, both of which replace keratocy...

متن کامل

Myofibroblastic Malignancies – a Continuing Controversy

THE MYOFIBROBLAST Myofibroblasts are modified fibroblasts which were first identified in granulation tissue, where they are probably derived from local fibroblasts, and which form the principal component of a number of reactive and benign soft tissue lesions. Under mechanical stress, the fibroblasts acquire cytoplasmic actin-containing microfilaments or stress fibres which express β−and γ-actin...

متن کامل

Coordinated reassembly of the basement membrane and junctional proteins during corneal epithelial wound healing.

PURPOSE To characterize changes in the localizations of the basement membrane protein laminin-1 and of adhesion proteins of intercellular junctions during wound healing after epithelial ablation in the rat cornea. METHODS Epithelial ablation was performed with an excimer laser. Rats were killed immediately, 12 hours, 24 hours, 3 days, or 4 weeks after ablation, and corneal cryosections were s...

متن کامل

Smooth Muscle α Actin (Acta2) and Myofibroblast Function during Hepatic Wound Healing

Smooth muscle α actin (Acta2) expression is largely restricted to smooth muscle cells, pericytes and specialized fibroblasts, known as myofibroblasts. Liver injury, associated with cirrhosis, induces transformation of resident hepatic stellate cells into liver specific myofibroblasts, also known as activated cells. Here, we have used in vitro and in vivo wound healing models to explore the func...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of Cell Biology

دوره 76  شماره 

صفحات  -

تاریخ انتشار 1978